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Accueil du site > Equipes de recherche > Equipe CMO (N.Ravel, N.Buonviso) > Thématique 2

Axe 2

par Jane Plailly, Nicolas Fourcaud-Trocme, Philippe Litaudon - 28 novembre 2012

Centre de Recherche en Neuroscience de Lyon

 Team :
Coding and memory in olfaction

 Axis :
Neural dynamics and information representations

Overview

The central question of this axis is the importance of temporal dynamics, particularly oscillatory rhythms, in information processing. By the uniqueness of its structural, anatomical, and electrical features, the olfactory system provides a good model for studying oscillatory dynamics :

  • The olfactory stimulus occurs in a rhythmic stream (related to sniffing) [1]. During periods of active sampling, this rhythm reaches the theta frequency range.
  • Different fast oscillatory regimes (beta, gamma) exist in a prominent way and particularly appear with the same frequency ranges both in anesthetized and awake rodent [2].
  • Odor information is relayed directly to the limbic structures such as amygdala and hippocampus which play critical role in specific forms of memories. It turns out that oscillatory activities in olfactory structures and limbic areas are highly modified by learning [3].
  • The active sampling in olfaction is the sniffing which is an olfactomotor act. During sniffing, important oscillatory activities appear in olfactory, somatosensory, limbic, and motor structures.

These characteristics make the olfactory network a relevant model to explore neuronal computation related to brain rhythms. This makes the olfactory system a unique model to explore how oscillatory activities underlie the neural networks involved in memory function and for studying the coordination and entrainment between a sampling-imposed rhythm and a network-emerging one during a goal-directed behavior.

Researchers

AMAT Corine
BUONVISO Nathalie
FOURCAUD-TROCME Nicolas
KUCZEWSKI Nicola
LITAUDON Philippe
RAVEL Nadine

Current projects

Project 1 : Mechanistic process of oscillatory rhythms - Anesthetized preparation. (Corine Amat, Nathalie Buonviso, Philippe Litaudon, Nicola Kuszewski , Nicolas Fourcaud-Trocmé).

Project 2 : Informational content of spiking activity during gamma and beta episodes - Anesthetized and awake preparations (Nathalie Buonviso, Nicolas Fourcaud-Trocmé, Philippe Litaudon ).

Project 3 : Flexibility of dynamical networks – Behaving animal (Nathalie Buonviso, Nicolas Fourcaud-Trocmé, Nadine Ravel).

Selected publications

 


[1] Buonviso N, Amat C, Litaudon P. Respiratory modulation of olfactory neurons in the rodent brain. Chemical senses. 31(2):145-154. Available at: http://www.ncbi.nlm.nih.gov/pubmed/16339270.

[2] Cenier T, David F, Litaudon P, Garcia S, Amat C, Buonviso N. Respiration-gated formation of gamma and beta neural assemblies in the mammalian olfactory bulb. The European journal of neuroscience. 29(5):921-930. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19291223.

[3] Ravel N, Chabaud P, Martin C, et al. Olfactory learning modifies the expression of odour-induced oscillatory responses in the gamma (60-90 Hz) and beta (15-40 Hz) bands in the rat olfactory bulb. The European Journal of Neuroscience. 17(2):350-358. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12542672.