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Accueil du site > Equipes de recherche > Equipe CMO (N.Ravel, N.Buonviso) > Thématique 3

Axe 3

par Jane Plailly, Nicolas Fourcaud-Trocme, Philippe Litaudon - 7 décembre 2012

Centre de Recherche en Neuroscience de Lyon

 Team :
Coding and memory in olfaction

 Axis :
Neural bases of olfactory experience

Overview

The perception of an odor, our ability to recognize it, to distinguish it even from a very similar one, results from our daily olfactory experience. This axis brings together research projects aimed at understanding how olfactory representations are built up across successive odour experiences and how they may, in turn, modulate odor perception and recollection of associated information.
Our group has been one of the first to stress the importance of so-called “sensory areas” such as olfactory bulb and piriform cortex in olfactory memory circuits. On the basis of anatomy, odour information has a privileged access to the limbic system (no thalamic relay to reach the cortex). Sensory olfactory structures established strong reciprocal interactions with structures traditionally involved in memory processes such as amygdala, hippocampus, or entorhinal cortex. Indeed, previous work from our group and others, in humans as well as in rodents, has brought evidence for a distributed olfactory memory network. Moreover, more recently, we demonstrated that the structures involved in this circuit are largely dependent from those recruited by the initial olfactory experience. We confirmed that sensory areas not only modified their functional activity but also sustained strong structural changes when experience extended to expertise as it was the case with perfumers. Current studies in the team are aimed at a better understanding of respective role of sensory and associative areas and their interaction in olfactory learning tasks from a simple odour-reward association to a complex multimodal episode including olfactory cues.
 

Researchers

 
Current projects

Project 1 : Simple forms of associative memories (Barbara Ferry, Nicolas Kuczewski, Anne-Marie Mouly)

Project 2 : Olfacto-tactile multisensory associations (Barbara Ferry, Rémi Gervais)

Project 3 : A complex form of associative memory : episodic memory (Jane Plailly, Nadine Ravel, Jean-Pierre Royet, Damien Gervasoni)
 
Selected publications
Ferry B, Viret P : The orexin component of fasting triggers memory processes underlying conditioned food selection in the rat. Learn Mem 2014, 21 : 185-189.
 
Meunier D, Fonlupt P, Saive A-L, Plailly J, Ravel N, Royet J-P : (2014) Modular structure of functional networks in olfactory memory. Neuroimagein Press doi:10.1016/j.neuroimage.2014.03.041
 
Saive AL, Ravel N, Thevenet M, Royet JP, Plailly J : A novel experimental approach to episodic memory in humans based on the privileged access of odors to memories. J Neurosci Methods 2013, 213(1):22-31.
 
Plailly J, Delon-Martin C, Royet JP : Experience induces functional reorganization in brain regions involved in odor imagery in perfumers. Hum Brain Mapp 2012, 33(1):224-234.
 
Sevelinges Y, Mouly AM, Raineki C, Moriceau S, Forest C, Sullivan RM : Adult depression-like behavior, amygdala and olfactory cortex functions are restored by odor previously paired with shock during infant’s sensitive period attachment learning. Dev Cogn Neurosci 2011, 1(1):77-87
 
Chapuis J, Garcia S, Messaoudi B, Thevenet M, Ferreira G, Gervais R, Ravel N : The way an odor is experienced during aversive conditioning determines the extent of the network recruited during retrieval : a multisite electrophysiological study in rats. J Neurosci 2009, 29(33):10287-10298.