Centre de Recherche
       en Neurosciences de Lyon

    UCBL1 - CNRS UMR5292 - INSERM U1028




Sur ce site

Sur le Web du CNRS

Accueil du site > Equipes de recherche > Equipe CMO (N.Ravel, N.Buonviso) > Thématique 4

Centre de Recherche en Neuroscience de Lyon

 Team :
Coding and memory in olfaction

 Axis :
Modulation of olfactory processing in normal and pathological eating behaviors


Olfaction and eating behaviors are intimately intermingled. Olfaction takes part in each step of the food intake from food choice, to its consumption. At the reverse, satiation reduces olfactory perception which contributes in meal interruption. Thus, olfactory cued reward responses to food stimuli are one of the important factors controlling food intake. In the face of obesity epidemic and the prevalence of various kinds of eating disorders, it is essential to better understand how olfaction is modulated by the nutritional status in a normal context and in which extend it is disrupted in pathological eating behaviors.
To address these questions, we propose a multidisciplinary set of convergent and interactive approaches to better understand the cellular basis of the olfactory sensitivity to metabolic cues and to characterize the olfactory processing in various pathological context (i.e. metabolic or eating disorders).




Current projects

Project 1. The olfactory signal under metabolic influence : studies on rodents (A.K. Julliard, N. Kuczewski, B. Paulignan, P. Viret, B. Ferry)

- The olfactory bulb as a gluco-sensor (A.K. Julliard, B. Paulignan)

- Role of molecules modulating food-intake (A.K. Julliard N. Kuczewski, B. Paulignan, P. Viret)

- Modulation of olfactory memory by orexin (B. Ferry, P. Viret)
Project 2. The importance of olfactory signal in food-intake : studies on humans
- Importance of internal state in appetence of food odors (Plailly J, Royet JP)
- Role of olfactory- and visual-cued reward responses in the control of food intake (Jiang T, Royet JP in collaboration with the CESG, Dijon)

Selected publications

Ferry B, Viret P : The orexin component of fasting triggers memory processes underlying conditioned food selection in the rat. Learn Mem 2014, 21 : 185-189.

Kuczewski N, Fourcaud-Trocme N, Savigner A, Thévenet M, Aimé P, Garcia S, Duchamp-Viret P, Palouzier-Pauligan B : Insulin modulates network activity in olfactory bulb slices : impact on odour processing. J Physiol. In Press

Jiang T, Schaal B, Boulanger V, Kontar F, Soussignan R : Children’s reward responses to picture- and odor-cued food stimuli : a developmental analysis between 6 and 11years. Appetite 2013, 67:88-98.

Aime P, Hegoburu C, Jaillard T, Degletagne C, Garcia S, Messaoudi B, Thevenet M, Lorsignol A, Duchamp C, Mouly AMand Julliard, AK : A physiological increase of insulin in the olfactory bulb decreases detection of a learned aversive odor and abolishes food odor-induced sniffing behavior in rats. PLoS One 2012, 7(12):e51227.

Palouzier-Paulignan B, Lacroix MC, Aime P, Baly C, Caillol M, Congar P, Julliard AK, Tucker K, Fadool DA : Olfaction under metabolic influences. Chem Senses 2012, 37(9):769-797.

Soussignan R, Schaal B, Boulanger V, Gaillet M, Jiang T : Orofacial reactivity to the sight and smell of food stimuli. Evidence for anticipatory liking related to food reward cues in overweight children. Appetite 2012, 58(2):508-516.

Plailly J, Luangraj N, Nicklaus S, Issanchou S, Royet JP, Sulmont-Rosse C : Alliesthesia is greater for odors of fatty foods than of non-fat foods. Appetite 2011, 57(3):615-622.