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Accueil du site > Equipes de recherche > Equipe CMO (N.Ravel, N.Buonviso) > Annuaire > Pages personnelles > Nathalie BUONVISO

Publications

par Nathalie Buonviso - 15 mars 2013

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2017


  • Fourcaud-Trocmé N, Briffaud V, Thévenet M, Buonviso N, Amat C. In vivo beta and gamma subthreshold oscillations in rat mitral cells: origin and gating by respiratory dynamics. Journal of Neurophysiology.:jn.00053.2017.
    Résumé : In mammals, olfactory bulb (OB) dynamics are paced by slow and fast oscillatory rhythms at multiple levels: local field potential, spike discharge, and/or membrane potential oscillations. Interactions between these levels have been well studied for the slow rhythm linked to animal respiration. However, less is known regarding rhythms in the fast beta (10-35Hz) and gamma (35-100Hz) frequency ranges, particularly at the membrane potential level. Using a combination of intracellular and extracellular recordings in the OB of freely breathing rats, we show that beta and gamma subthreshold oscillations (STO) coexist intracellularly and are related to extracellular LFP oscillations in the same frequency range. However, they are differentially affected by changes in cell excitability and by odor stimulation. This leads us to suggest that beta and gamma STOs may rely on distinct mechanisms: gamma STOs would mainly depend on mitral cell intrinsic resonance while beta STOs could be mainly driven by synaptic activity. In a second part, we found that STO occurrence and timing are constrained by the influence of the slow respiratory rhythm on mitral/tufted cells. First, respiratory-driven excitation seems to favor gamma STOs while respiratory-driven inhibition favors beta STOs. Second, the respiratory rhythm is needed at the subthreshold level in order to lock gamma and beta STOs in similar phases as their LFP counterparts and to favor the correlation between STO frequency and spike discharge. Overall, this study helps to understand how the interaction between slow and fast rhythms at all levels of OB dynamics shapes its functional output.
    Mots-clés : freely breathing anesthetized rat, mammalian olfactory bulb, odor stimulation, respiratory slow rhythm.

  • Martinez D, Clement M, Messaoudi B, Gervasoni D, Litaudon P, Buonviso N. Adaptive quantization of local field potentials for wireless implants in freely moving animals: an open-source neural recording device. Journal of Neural Engineering. 2017.
    Résumé : OBJECTIVE: Modern neuroscience research asks for electrophysiological recording of local field potentials (LFPs) in moving animals. Wireless transmission has the advantage of removing the wires between the animal and the recording equipment but is hampered by the large amount of data to be sent at a relatively high rate. APPROACH: To reduce transmission bandwidth, we propose an encoder/decoder scheme based on adaptive non-uniform quantization. Our algorithm uses the current transmitted codeword to adapt the quantization intervals to changing statistics in LFP signals. It is thus backward adaptive and does not require sending side information. The computational complexity is low and similar at the encoder and decoder side. These features allow for real-time signal recovery and facilitate hardware implementation with low-cost commercial microcontrollers. MAIN RESULTS: As proof-of-concept, we developed an open-source Neural Recording Device called NeRD. The NeRD prototype digitally transmits 8 channels encoded at 10 kHz with 2 bits per sample. It occupies a volume of 2 × 2 × 2 cm3 and weighs 8 grams with a small battery allowing for 2 hours 40 min of autonomy. The power dissipation is 59.4 mW for a communication range of 8 m and transmission losses below 0.1%. The small weight and low power consumption offers the possibility to mount the entire device on the head of rodents without resorting to separate head-stage and battery backpack. The NeRD prototype is validated in recording LFPs in freely moving rats at 2 bits per sample while maintaining an acceptable signal-to-noise ratio (>30 dB) over a range of noisy channels. SIGNIFICANCE: Adaptive quantization in neural implants allows for lower transmission bandwidths while retaining high signal fidelity and preserving fundamental frequencies in LFPs.
    Mots-clés : Local field potential, Neural implants, Neural telemetry, Neurophysiology, Neurotechnology, Wireless transmission.

2016


  • Buonviso N, Dutschmann M, Mouly A-M, Wesson DW. Adaptation and Plasticity of Breathing during Behavioral and Cognitive Tasks. Neural Plasticity. 2016:2804205.