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       en Neurosciences de Lyon

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Accueil du site > Equipes de recherche > Equipe CMO (N.Ravel, N.Buonviso) > Annuaire > Pages personnelles > Nicola KUCZEWSKI


par Nicola Kuczewski - 27 janvier 2014


Associate Professor, Lyon 1 University

Bureau : 103
Téléphone : + 33 (0)4 37 28 74 62
Fax : +33 (0)4 37 28 76 01
e-mail : Nicola.Kuczewski[at]univ-lyon1.fr


We generally assume that the information in the brain is carried by the neuronal firing. Depending on the brain structure and the neuronal type the information appears to be coded either by the frequency or by the temporal structure of the firing. In addition to this classical view some evidence suggests that part of the neuronal information can be coded as well by the shape of the spike. Indeed it has been shown that the duration and/or the amplitude of the action potential can affect the release of neurotransmitter and, as a consequence, the impact on the postsynaptic target. My main research topic is the study of the cellular biophysical mechanisms, such as the afterhyperpolarization (AHP), affecting the action potentials emission, timing and shape. The goal is to determine whether and how neuromodulators (acetylcholine and noradrenalin) and learning process impact neuronal coding by affecting those mechanisms. To this aim I use in vitro electrophysiology (patch clamp recording) and optical imaging on olfactory bulb slices issue from rodents submitted to olfactory learning.