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Accueil du site > Equipes de recherche > Equipe CMO (N.Ravel, N.Buonviso) > Annuaire > Pages personnelles > Alexandra VEYRAC

Alexandra VEYRAC

Présentation

par Alexandra Veyrac - 5 février 2014

 

Alexandra VEYRAC
Post-Doc Labex Cortex 2013-2014

Office : 221
Phone : + 33 (0)4 37 28 74 98
Fax : +33 (0)4 37 28 76 01
e-mail : Alexandra.Veyrac[at]cnrs.fr

Research Associate, Centre de Neurosciences Paris-Sud (CNPS), CNRS UMR8195, Université Paris-Sud XI, Orsay


 


Research interests

The main objective of my research is to identify mechanisms of plasticity in the adult brain that underlie memory. Using rodent models (rats and transgenic mice), I previously asked how different key mechanisms of plasticity, such as noradrenalin, Collapsin Response Mediator Proteins, estrogens, the Immediate Early Gene Zif268/Egr1 and the formation of new neurons in the adult olfactory bulb and hippocampus, contribute to specific phases and processes of memory (learning, recall and consolidation).
Recently, I focused my attention on a complex from of memory ; the episodic memory which is characterized by the encoding, consolidation and recollection of unique past experience, including “What” happened, “Where” and “When-In which context”. In collaboration with Serge Laroche Lab (CNPS, CNRS UMR8195, Université Paris-Sud XI, Orsay) and colleagues working in Humans in the team, we have developed a novel framework and paradigm that provides means to evaluate, in a situation as close as possible to the paradigm developed in Humans, the ability of rats to form and recollect a combined long-term episodic-memory of odors (What) encountered in distinct locations (Where) in given multisensory enriched environments (In Which context).
This paradigm offers us the possibility to investigate genetic, molecular, neurophysiological mechanisms and network dynamics that underlie encoding and faithful recollection of past events.

Technical Skills :

-Surgery : stereotaxic injection of viral vectors, implantation for chronic hormonal treatment, olfactory sensory deprivations

-Behavior : episodic-like memory, spatial learning radial and water maze, perceptual olfactory learning, non-associative olfactory memory, olfactory passive stimulation, socio-sexual behavior, olfactory and environmental enrichment, locomotion behavior

-Pharmacology : acute and chronic treatment of noradrenergic agents

-Cellular and Molecular Biology : Immunohistochemistry, HIS, RT-PCR, Western Blotting, adult neural stem cells culture, viral and non-viral cell transfection, design of siRNA

-Imaging analysis : Optical and Confocal microscopy (Leica, Zeiss, Olympus), brain stereology

Short CV

2005 : PhD in Neuroscience, Laboratoire Neurosciences Systèmes Sensoriels, University Lyon. Molecular and cellular mechanisms of neurogenesis regulation in the adult mouse olfactory system.
Dir Pr François Jourdan

2007-2008 : Post-doc Dipartimento di Biologia Animale e dell’Uomo, University Turin, Italy.
Sensory experience and functional integration of adult newborn neurons in the mouse Olfactory Bulb.
Dir Silvia De Marchis

2008-2009 : Post-doc Cellular and Molecular Neurobiology Center, University Liège, Belgium.
Role of estrogens in the adult mouse olfactory neurogenesis and socio-sexual behavior.
Dir Julie Bakker

2009-2013 : Post-doc Centre de Neurosciences Paris-Sud, University Paris-Sud XI, Orsay.
Role of the IEG Zif268 in the adult hippocampus neurogenesis, plasticity and memory.
Dir Serge Laroche

2000-2006 : Teaching lecturer Licence, Master Physiology and Neuroscience, University Lyon (292h)
2005-2014 : Supervision 6 students (Master 1 and 2) ; Co-advisor of 1PhD.
2009-2014 : Associate member Faculty of 1000
2001-2006 ; 2011-2013 : Elected member Laboratory Council
2010-2014 : Co-principal Investigator ANR project (2010-BLAN-1413-01) MolCellCog