par, - 5 mai 2014
Bureau : 221
Téléphone : + 33 (0)4 37 28 74 98
In brief : Understanding the role of brain states and oscillatory neuronal activities in learning and memory by using multiple extracellular recordings in freely behaving rodents
Most brain functions in Mammals, ranging from perception to memory formation, involve multiple anatomical regions. In order to understand how the brain builds and keep traces of representations of the world it is thus essential to access simultaneously to several brain areas and try to follow and decipher their interactions. For this purpose, I am developing and implementing electrophysiological techniques in behaving animals. Multiple microelectrodes are used to record continuous (local field potentials) and discrete (action potentials) neuronal signals from distinct cortical and subcortical structures involved in odor memory formation, with a peculiar attention on oscillatory activities. As a former student of Pr Michel Jouvet and a sleep researcher for about twenty years, I keep being interested in sleep and its beneficial role in learning and memory.
Ethics in animal research
The use of animals in research still remains an intensely debated question. Its necessity and acceptability are matters of widely varying opinions, mainly based on moral convictions. There is, however, a consensus to allow the use of animals for scientific purpose as long as Human or animal health in particular are concerned and no valid alternative method exists to reach the objective. A part of my work is devoted to ethics in animal experimentation, as a member of our institutional ethics committee, a teacher in experimental surgery (without live animals), and a supporter of the 3R principle(*) and alternatives to animal use.
(*) Replacement, Reduction, and Refinement in “The Principles of Humane Experimental Technique” by William Russell and Rex Burch (1959)