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Accueil du site > Equipes de recherche > Equipe CMO (N.Ravel, N.Buonviso) > Annuaire > Pages personnelles > Barbara FERRY


par Philippe Litaudon - 14 mai 2014


  • Boisselier L, Gervasoni D, Garcia S, Ferry B, Gervais R. Neuronal dynamics supporting formation and recombination of cross-modal olfactory-tactile association in the rat hippocampal formation. Journal of Neurophysiology. 2017:jn.00666.2017.
    Résumé : The present study is aimed at describing some aspects of the neural dynamics supporting discrimination of olfactory-tactile paired-associated stimuli during acquisition of new pairs and during recombination of previously-learned pairs in the rat. To solve the task, animals have to identify one odor-texture (OT) combination associated with a food reward among three cups with overlapping elements. Previous experiments demonstrated that the lateral entorhinal cortex (LEC) is involved in the processes underlying OT acquisition while the dorsal hippocampus (DH) is selectively involved in the recombination processes. In the present study, local field potentials were recorded form the anterior piriform cortex (aPC), the LEC and the DH in freely moving rats performing these tasks. Signal analysis focused on theta (5-12 Hz) and beta band (15-40 Hz) oscillatory activities both in term of amplitude and synchrony. The results showed that cue sampling was associated with a significant increase in the beta band activity during the choice period in both the aPC and the LEC, and is modulated by level of expertise and animal's decision. In addition, this increase was significantly higher during the recombination when compared to the acquisition of the OT task, specifically when animals had to neglect the odor previously associated with the reward. Finally, a significant decrease in coherence in the theta band between LEC and DH was observed in the recombination but not in the acquisition task. These data point to specific neural signatures of simple and complex cross-modal sensory processing in the LEC-DH complex.
    Mots-clés : behavioral flexibility, cross-modal, hippocampus, lateral entorhinal cortex, olfactory-tactile.


  • Laurent C, Burnouf S, Ferry B, et al. A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. Molecular Psychiatry. 21(1):97-107.
    Résumé : Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer's disease (AD) in humans and mitigates both amyloid and Tau burden in transgenic mouse models. However, the impact of selective A2AR blockade on the progressive development of AD-related lesions and associated memory impairments has not been investigated. In the present study, we removed the gene encoding A2AR from THY-Tau22 mice and analysed the subsequent effects on both pathological (Tau phosphorylation and aggregation, neuro-inflammation) and functional impairments (spatial learning and memory, hippocampal plasticity, neurotransmitter profile). We found that deleting A2ARs protect from Tau pathology-induced deficits in terms of spatial memory and hippocampal long-term depression. These effects were concomitant with a normalization of the hippocampal glutamate/gamma-amino butyric acid ratio, together with a global reduction in neuro-inflammatory markers and a decrease in Tau hyperphosphorylation. Additionally, oral therapy using a specific A2AR antagonist (MSX-3) significantly improved memory and reduced Tau hyperphosphorylation in THY-Tau22 mice. By showing that A2AR genetic or pharmacological blockade improves the pathological phenotype in a Tau transgenic mouse model, the present data highlight A2A receptors as important molecular targets to consider against AD and Tauopathies.


  • Ferry B, Parrot S, Marien M, Lazarus C, Cassel J-C, McGaugh JL. Noradrenergic influences in the basolateral amygdala on inhibitory avoidance memory are mediated by an action on α2-adrenoceptors. Psychoneuroendocrinology. 51:68-79.
    Résumé : The role of norepinephrine (NE) in the consolidation of inhibitory avoidance learning (IA) in rats is known to involve α1- and β-adrenoceptor systems in the basolateral nucleus of the amygdala (BLA). However, the amygdala also contains α2-adrenoceptor subtypes, and local microinfusions of the selective α2-adrenoceptor antagonist idazoxan and agonist UK 14,304 respectively into the BLA enhance and inhibit IA performances when administered before acquisition. The present study investigated whether the effects of idazoxan and UK 14,304 on IA were associated with changes in NE release within the BLA before and after one-trial inhibitory avoidance training. Male Sprague-Dawley rats were unilaterally implanted with a microdialysis probe in the BLA and were administered idazoxan (0.1mM) or UK 14,304 (10 μM) by retrodialysis infusion 15 min before the acquisition of IA. Dialysates were collected every 15 min for analysis of NE. Retrodialysis of idazoxan potentiated the release of NE induced by footshock application, whereas UK 14,304 decreased NE release to the extent that the footshock failed to induce any measurable effect on NE levels. Idazoxan infusion enhanced IA retention tested 24h later and this effect was directly related to the level of NE release in the BLA measured during IA acquisition. In contrast, the infusion of UK 14,304 did not modify IA performances in comparison to control animals, possibly due to compensatory activity of the contralateral BLA. These results are consistent with previous evidence that amygdala NE is involved in modulating memory consolidation, and provide evidence for an involvement of presynaptic α2-autoceptors in the BLA in this process.
    Mots-clés : Adrenergic alpha-2 Receptor Agonists, Adrenergic alpha-2 Receptor Antagonists, Animals, Avoidance Learning, Basolateral amygdala, Basolateral Nuclear Complex, Brimonidine Tartrate, Idazoxan, Inhibitory avoidance learning, Male, Memory, Memory modulation, Microdialysis, Norepinephrine, Quinoxalines, Rats, Rats, Sprague-Dawley, Receptors, Adrenergic, alpha-2, Retrodialysis, α(2)-Adrenoceptor.